A head-on collision between two vehicles in St. Paul killed one driver and critically injured the other, police said.

Officers were called to the crash in the area of Shepard Road and Otto Street shortly after 2:30 a.m. Sunday.

St. Paul Fire Department medics pronounced a man dead at the scene who’d been driving a sedan, said Nikki Muehlhausen, a St. Paul police spokeswoman. A woman in the car sustained moderate injuries and paramedics took her to Regions Hospital.

A man driving a pickup had life-threatening injuries and was also taken to Regions, Muehlhausen said.

Police continue to investigate the cause of the crash.

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