For the first time this season, the Celtics were without Jayson Tatum on Wednesday night.

Boston ruled out the three-time All-NBA first-teamer for its matchup with the Detroit Pistons at TD Garden with right patella tendinopathy. Starting guard Jrue Holiday (left knee tendinopathy) also was ruled out for the second consecutive game.

Tatum was listed as questionable for Monday’s matchup with Miami but wound up playing 36 minutes in a 108-89 Celtics win. Head coach Joe Mazzulla praised the superstar for his aversion to taking nights off, saying: “You walk into the arena and know you have a chance to win every night, because your best players want to play, and they can play, and that they take care of themselves.”

Mazzulla said Tatum’s knee injury is “just something that he continues to work through” and that he does not expect him to miss more than one game.

“I know he’s OK,” the coach said. “He’s getting better every day.”

Wednesday’s game was the first that Tatum missed all season. It was the second straight DNP for the 34-year-old Holiday, who was listed on the Celtics’ injury report with left knee tendinopathy.

Tatum was recognized Tuesday as the Eastern Conference Player of the Month for November. He’s the NBA’s sixth-leading scorer this season and the Celtics’ leader in points, assists, rebounds and steals per game. Three-time NBA MVP Nikola Jokic is the only other player pacing his team in all four categories.

“Jayson makes everything easier for everyone else around him,” reserve wing Sam Hauser said Wednesday morning. “He draws so much attention to himself that it gives other guys open looks. It gives them open reads, and we’re there as outlets for him. He trusts us enough to where he’s willing to give the ball up when two guys are on him to make the easy, right play, and I think that’s where he’s grown in the last three, four years — just making the right play. It might not be flashy or anything, but I think if you’re doing the right thing consistently most of the time, then it shows.

“And obviously he’s still putting up great numbers in other aspects, but I think it’s just the little things that stand out.”

Hauser, Kristaps Porzingis and Al Horford all returned to action Wednesday after sitting out Monday’s win.

With Tatum’s streak ending, Payton Pritchard now is the only Celtics player to see action in every game this season.