An ankle injury sidelined Kristaps Porzingis for the second consecutive game Sunday.

The Celtics ruled out the starting center for their matchup with the Indiana Pacers at TD Garden. Porzingis also missed Friday’s 142-105 win over the Pacers after spraining his left ankle in Boston’s Christmas Day loss to Philadelphia.

Porzingis sat out the first 17 games following offseason surgery to repair the rare lower leg injury he suffered during the NBA Finals. Since his Nov. 25 season debut, he’s missed an additional four games and suffered three injuries — two to his left ankle and one to his right heel.

In the 11 games he has played this season, Porzingis has averaged 24.2 points, 8.4 rebounds and 1.9 blocks per 36 minutes. He’s greatly improved the Celtics’ rim protection, but his shot has been inconsistent, with his field-goal percentage (45.5%) and 3-point shooting percentage (32.8%) both down from last season’s marks (51.6% and 37.5%, respectively).

The Celtics did get one starter back Sunday, removing guard Jrue Holiday from their injury report ahead of the Pacers rematch. Holiday missed the previous two games with a right shoulder impingement. His shooting numbers also have dipped, with his success rate on 3-pointers dropping nearly 10 points from last season (42.9% to 32.6%).

Boston’s preferred starting five of Jayson Tatum, Jaylen Brown, Derrick White, Holiday and Porzingis has played just 85 minutes together this season — just 5.7% of the team’s total minutes through 31 games. The Celtics have been outscored by 5.8 points per 100 possessions with that group on the floor, the third-worst mark of any Boston lineup entering Sunday.

Eleven different Celtics players have started at least one game.

“One of the things that doesn’t get necessarily talked about: Last year, I felt like we were pretty healthy throughout,” Al Horford, who’s made 21 starts in 24 appearances, said after Wednesday’s loss to Philly. “And I think this year has been a lot of in-and-outs and guys filling in and guys doing this and doing that. So there’s different dynamics. It’s just different. I just think we continue to figure it out.”