FOXBORO — Patriots wide receivers Demario Douglas and Kayshon Boutte were both absent at the start of practice Friday, the team’s last before kicking off against the Chargers this weekend.

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Douglas is almost assuredly out for Sunday’s game, having missed all three practices this week with a concussion. The sixth-round rookie is the Pats’ leading receiver. His absence should allow for more opportunities for JuJu Smith-Schuster, Tyquan Thornton and Jalen Reagor.

Boutte missed Thursday’s session with a new illness and lingering shoulder injury. Offensive tackle Riley Reiff returned for warmups Friday after being limited Wednesday and sitting out Thursday with the same knee injury that put him on injured reserve weeks ago.

The Patriots will release their final injury report of the week around 4 p.m. Friday.