NEW YORK –  For the first time in over four decades, the Red Sox will have to find their voice.

Joe Castiglione, the award-winning voice of Red Sox radio for 42 seasons and over 6,500 games, will retire at season’s end, he announced in the fourth inning of Sunday’s Red Sox-Yankees game.

“While I feel I am at the pinnacle of my career, have been blessed to call four World Championships, and received the Ford C. Frick Award from the Hall of Fame in July while working for the greatest franchise in sports, it’s time to spend more time with Jan, my bride of almost 53 years, my kids, and grandkids,” Castiglione said in a press release issued by the Red Sox.

“Joe is one of the greatest in baseball broadcasting,” said Red Sox Principal Owner John Henry in the release, which noted that Castiglione plans to remain with the organization in an honorary ambassador role. “His brilliance in the booth is matched only by his exceptional character.”

Generations of baseball fans have hung on Castiglione’s every word. With genuineness and passion, he took Red Sox Nation through the final two decades of the 86-year championship drought, and into glory days. Unfailingly kind, the Red Sox Hall of Famer has brought goodness and humor to the most frustrating contests, comfort in times of heartbreak, and amplified the best moments with joy. His “Can you believe it?” call after the final out of the 2004 World Series is legendary.

The Red Sox will honor Castiglione before their final game of the regular season, on Sept. 29 at Fenway Park. Fitting, because it’s impossible to imagine the soundtrack of future Boston summers without him.