Minnesota led New York by two at the break Monday in Minneapolis.

Then came the third frame, when the Timberwolves dominated in the way the home crowd has become accustomed to seeing them do to opponents this season.

Minnesota outscored the Knicks 35-19 in the frame, holding New York to just 6-for-23 shooting, to key its 117-100 victory to move to 6-0 at Target Center this fall.

Minnesota has been one of the NBA’s better teams across the board this season. But, at home specifically, the Wolves appear to be an unstoppable force. Not only do they have impressive home victories over the likes of Boston and Denver, but they’ve also decimated a number of opponents on the Target Center floor.

“Our fans have been great. So being able to play well in front of them, I think that builds a ton of momentum for us,” Wolves forward Kyle Anderson said Monday morning. “And I think the weather might play a little factor, too. Guys are a little cold when they come up here and play. So I don’t know, it’s just fun playing at home really in the NBA.”

Minneapolis is where the Timberwolves’ defense appears to be at the peak of its powers. The Knicks struggled mightily from the field Monday, firing just 35% from the field and 24% from 3-point range.

Poor shooting is the Knicks’ M.O., but New York generally makes up for it with a lack of turnovers and a domination of the offensive glass. Both were prevalent again Monday — the Knicks grabbed 17 offensive rebounds — but Minnesota managed to turn away New York’s second and third attempts, as well.

Minnesota’s offense didn’t fair much better in the first half. But the Wolves started to convert on the offensive end in the third frame. The Wolves opened the quarter on an 11-0 run to space out the bout and never really looked back.

Anthony Edwards finished with 23 points, while Karl-Anthony Towns added 20 more.

It was a strong start to a jam-packed week at Target Center. Minnesota (10-3) hosts Philadelphia on Wednesday and Sacramento on Friday. Those two teams, like the Knicks (8-6), figure to not only be strong playoff teams, but candidates to make a postseason run.

A clean sweep of those contests this week would help cement Target Center as perhaps the best home-court advantage in the NBA this season — a distinction previously not associated with the downtown Minneapolis venue.

“You always love going on the road and getting a stop or playing well and getting a win,” Anderson said. “But at home, with your fans behind you, it gives you that edge, gives you that advantage.”