LIDO, Venice, Italy – Guillermo del Toro has fulfilled a childhood obsession with his extravagant, deeply personal take on Mary Shelley’s “Frankenstein.”

Netflix streams “Frankenstein” globally on Friday.

For Oscar Isaac, born in Guatemala 46 years ago but raised in America, mad Dr. Victor Frankenstein is both freshly conceived and a continuation of his anti-heroes who are intimately familiar with darkness of the soul.

A doctor who combines many corpses to animate a monster, it’s known here as the Creature (and embodied by six-foot-five Jacob Elordi).

Unlike Boris Karloff’s grotesque Monster in Hollywood’s 1931 horror classic, del Toro’s Creature is, above all, beautiful.

Isaac noted that every telling of Mary Shelley’s novel has, “The similar idea of the Creature and the creator — the mad scientist kind of thing.

“But early on we approached Victor more as an artist, and less of a scientist. You see it in the way he expresses himself, the way he dresses and the way he moves. You see that it comes from a much more painful place.

“I feel,” he continued, “this is ultimately about outsiders. People that feel on the outside. I look back at the roles I’ve done — I’ve always felt I’m ‘behind a glass darkly.’ Not really trying to participate in existence but lying on the outside.

“This film feels particularly personal that way. It also asks, How do you live with a broken heart? And what do you do with a broken heart? Often cruelty happens out of broken hearts.

“Everything that’s happening is Victor trying to control the aftermath of a heart just completely broken. In that way Victor feels in some ways more sensual and pleasurable a character as well.”

Isaac’s versatility, his hallmark, has let him avoid typecasting. How exactly has he managed that?

“I don’t know. I think it is a process of surrendering to the material in some way. And it’s about finding a way to fall in love with whatever it is so much you’re willing to give over to it completely.

“With Victor Frankenstein, I mean I can’t believe I’m here! That I got here from a place two years ago where I was sitting at Guillermo’s table, eating Cuban pork and talking about our fathers and our life.

“Then him saying, ‘I want you to be Victor. I’m creating this banquet for you. All you have to do is show up and eat.’

“And that was the truth. There was a fusion. I just hooked myself into Guillermo and we flung ourselves down the well.

“It really is a testament to how he poured his heart into it and inspired all of us to do the same thing.”