Marcelo Mayer has officially arrived.

The top Red Sox prospect will start at third base and bat sixth for the Red Sox when he makes his major league debut in the second game of Saturday’s doubleheader against the Baltimore Orioles.

Lucas Giolito (1-1, 7.08) will take the mound for the Red Sox against Orioles left-hander Trevor Rogers (season debut).

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Mayer was selected No. 4 overall in the 2021 MLB Draft and has ranked as one of Boston’s most highly touted young players ever since. He currently ranks as the No. 8 prospect in MLB according to Baseball America and is Boston’s No. 2 prospect behind outfielder Roman Anthony, the consensus top prospect in the sport.

Mayer becomes the second of Boston’s “Big Three” prospects to reach the majors this season, joining fellow infielder Kristian Campbell, who made the club out of spring training and will be batting cleanup for the Red Sox on Saturday evening.

Red Sox lineup

Jarren Duran LF

Rafael Devers DH

Rob Refsnyder RF

Kristian Campbell 2B

Trevor Story SS

Marcelo Mayer 3B

Nick Sogard 1B

Connor Wong C

Ceddanne Rafaela CF

Lucas Giolito P

How to watch

When: 6:35 p.m.

Where: Fenway Park, Boston

Broadcast info: NESN, WEEI 93.7 FM, WCCM 1490 AM (Spanish), WESX 1230 AM (Spanish)