SAN FRANCISCO — Joe Ryan grew up in nearby Marin County, going to games as a kid to root on the San Francisco Giants at Oracle Park.

But his return to the ballpark as a major leaguer didn’t go quite to plan. Ryan gave up five runs — matching a season-high — and was hurt early by his defense in a 7-1 loss on Friday night at Oracle Park to the San Francisco Giants.

“Kind of from the start, we could have done some things differently,” manager Rocco Baldelli said. “I’m not saying that it all would have worked out if we did the opposite of what actually, the way it played out. We could have played better today. Could the game, in the middle of the game, have been a 3-3 game? Based on the way the game went, absolutely.”

It started almost immediately when Matt Wallner dove at a sinking liner off the bat of leadoff man Jorge Soler, but he was unable to catch it. As the ball bounced to the wall, Soler raced to third. He came around to score when the very next batter, former Twin LaMonte Wade Jr., hit a sacrifice fly.

An inning later, Brooks Lee made a low throw that Willi Castro at second base had to lean down to catch. Castro then lost the ball upon the transfer, and the Twins (53-41) were unable to turn what potentially could have been an inning-ending double play. That kept the inning alive, allowing two more runs to score in the inning.

Ryan gave up another run in the fifth and walked two batters to lead off the sixth. One of those inherited runners scored.

“They had a good plan tonight. Put some good swings on it,” Ryan said. “We didn’t play good defense and that’s usually how it shakes out. Got some extra long innings. Don’t get to go as deep into a game because of that and I just gassed out a little quicker.”

After his departure, Josh Staumont gave up a pair of runs in the seventh inning, sinking the Twins into an even larger hole. They were the first earned runs he had given up all season and they came in his 20th outing.

The Twins’ offense, meanwhile, was held to just a run despite plenty of hard contact. It was, notably, not a home run, meaning their bid to put themselves atop the record books fell just short.

Heading into Friday, the Twins had homered in 28 straight games, which had moved them into a tie for second place on Major League Baseball’s all-time list, behind just the 2019 Yankees, who accomplished the feat over 31 straight games.

“It’s probably one of the harder places to homer in,” Baldelli said of Oracle Park. ” … The streak was going to end at some point along the way. There’s no way to keep that going for an entire season. It was pretty impressive while it lasted though.”

Carlos Santana’s sixth-inning double brought home Carlos Correa for the Twins’ only run of the night against Giants (46-49) pitching.

“It was a game where we didn’t play our cleanest baseball today, we didn’t have good enough at-bats, we didn’t do enough,” Baldelli said. “Joe has been sharper previously, more so than he was today, we’ll have to get over it and just kind of move on from this one.”