By WAFAA SHURAFA and SAMY MAGDY

DEIR AL-BALAH, Gaza Strip (AP) — An apparent Israeli airstrike on a school-turned-shelter in southern Gaza killed at least 25 Palestinians on Tuesday, as heavy bombardment in the north forced the closure of medical facilities in Gaza City and sent thousands fleeing in search of increasingly elusive refuge.

Israel’s new ground assault in Gaza’s largest city is its latest effort to battle Hamas, which is regrouping in areas the army previously said had been largely cleared.

Hamas has been designated as a terrorist organization by the United States, Canada and the European Union.

Large parts of Gaza City and urban areas around it have been flattened or left a shattered landscape after nine months of fighting. Much of the population fled earlier in the war, but several hundred thousand Palestinians remain in the north.

“The fighting has been intense,” said Hakeem Abdel-Bar, who fled Gaza City’s Tuffah district to the home of relatives in another part of the city. He said Israeli warplanes and drones were “striking anything moving” and that tanks had moved into central districts.

The strike at the entrance to the school killed at least 25 people, according to an Associated Press reporter who counted the bodies at Nasser Hospital in Khan Younis. Hospital spokesperson Weam Fares said the dead included at least seven women and children and that the toll was likely to rise.

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Earlier airstrikes in central Gaza killed at least 14 people, including a woman and four children, according to two hospitals that received the bodies. Israel has repeatedly struck what it says are militant targets across Gaza since the start of the war nine months ago.

The military blames civilian deaths on Hamas because the group fights in dense, urban areas, but the army rarely comments on individual strikes, which often kill women and children. There was no immediate comment from the military on the strike on the school.

There was also no immediate word on casualties in Gaza City. Families whose relatives were wounded or trapped were calling for ambulances, but first responders could not reach most of the affected districts because of the Israeli operations, said Nebal Farsakh, a spokesperson for the Palestinian Red Crescent.

“It’s a dangerous zone,” she said.

After Israel on Monday called for an evacuation from eastern and central parts of Gaza City, staff at two hospitals — Al-Ahli and the Patients Friends Association Hospital – rushed to move patients and shut down, the United Nations said. Farsakh said all three medical facilities run by the Red Crescent in Gaza City had closed.

Scores of patients were transferred to the Indonesian Hospital in northern Gaza, which itself was the scene of heavy fighting earlier in the war. “We do not know where to go. There is no treatment and no necessities for life,” said Mohammad Abu Naser, who was being treated there. “We are dying slowly.”

The Israeli military on Tuesday said it had told hospitals and other medical facilities in Gaza City that they did not need to evacuate. But hospitals in Gaza have often shut down and moved patients at any sign of possible Israeli military action, fearing raids.

The Episcopal Church in the Middle East, which operates Al-Ahli, said the hospital was “compelled to close by the Israeli army” after the evacuation orders and a wave of nearby drone strikes on Sunday.

In the past nine months, Israeli troops have occupied at least eight hospitals, causing the deaths of patients and medical workers along with massive destruction to facilities and equipment. Israel has claimed Hamas uses hospitals for military purposes, though it has provided only limited evidence.

Only 13 of Gaza’s 36 hospitals are functioning, and those only partially, according to the U.N.’s humanitarian office.

Israel’s campaign in Gaza, triggered by Hamas’ Oct 7 attack, has killed or wounded more than 5% of Gaza’s 2.3 million Palestinians, according to the territory’s Health Ministry. Nearly the entire population has been driven from their homes. Many have been displaced multiple times. Hundreds of thousands are packed into sweltering tent camps.

The U.N. humanitarian office said the exodus in Gaza City was “dangerously chaotic,” with people instructed to flee through neighborhoods where fighting was underway.

“People have been observed fleeing in multiple directions, not knowing which way may be safest,” the agency said in a statement. It said the largest U.N. bakery in the city was forced to close, and that the fighting had blocked aid groups from accessing warehouses.

Maha Mahfouz, a mother of two, said she fled twice in the past 24 hours. She first rushed from her home in Gaza City to a relative’s house in another neighborhood. When that became dangerous, she fled Monday night to Shati, a decades-old refugee camp that has grown into an urban district where Israel has carried out repeated raids.

She described vast destruction in the areas targeted in the latest raids. “The buildings were destroyed. The roads were destroyed. All has become rubble,” she said.

The Israeli military has said it had intelligence showing that combatants from Hamas and the smaller Islamic Jihad group were regrouping in central Gaza City. Israel accuses Hamas and other fighters of hiding among civilians. In Shijaiyah, a Gaza City neighborhood that has seen weeks of fighting, the military said it had destroyed 6 kilometers (3 miles) of Hamas tunnels.

Hamas has warned that the latest raids in Gaza City could lead to the collapse of negotiations for a cease-fire and hostage-release deal.

Israel and Hamas had appeared to narrow the gaps in recent days, with the U.S., Egypt and Qatar mediating.

CIA Director William Burns met with Egyptian President Abdel Fattah el-Sissi on Tuesday in Cairo to discuss the negotiations, el-Sissi’s office said. More talks were to be held Wednesday in Qatar, where Hamas maintains a political office.

But obstacles remain, even after Hamas agreed to relent on its key demand that Israel commit to ending the war as part of any agreement. Hamas still wants mediators to guarantee that negotiations conclude with a permanent cease-fire.

Israel has rejected any deal that would force it to end the war with Hamas intact. Hamas on Monday accused Israeli Prime Minister Benjamin Netanyahu of “putting more obstacles in the way of negotiations,” including the operations in Gaza City.

Hamas’ cross-border raid on Oct. 7 killed 1,200 people in southern Israel, most of them civilians, according to Israeli authorities. The combatants took roughly 250 people hostage. About 120 are still in captivity, with about a third said to be dead.

Israel’s bombardment and offensives in Gaza have killed more than 38,200 people and wounded more than 88,000, according to the territory’s Health Ministry, which does not distinguish between combatants and civilians in its count.

Magdy reported from Cairo.