After missing all of spring training and the season’s first month due to a series of injuries, Vaughn Grissom is finally set to make his Red Sox debut tonight in Minnesota.

The new Red Sox second baseman was officially activated from the 10-day injured list and will start at second base and bat seventh as the club opens its three-game series against the Twins.

To clear space on the roster the Red Sox optioned first baseman Bobby Dalbec to Triple-A.

Grissom was initially sidelined with a groin strain suffered over the offseason and then experienced a setback when he suffered a left hamstring strain while ramping up during camp. Grissom spent 20 days on a rehab assignment at Triple-A Worcester throughout April, batting .333 with an .844 OPS in nine games with the WooSox, but was delayed once again after coming down with the flu on Tuesday.

In addition to Grissom, first baseman Garrett Cooper will get the start at first base, Dominic Smith will serve as the designated hitter, Reese McGuire will start at catcher and the rest of Boston’s regulars will take the field at their usual positions. Tanner Houck (3-2, 1.60 ERA) is set to start against Minnesota’s Chris Paddack (2-1, 5.88).

Red Sox lineup

Jarren Duran CF

Rafael Devers 3B

Tyler O’Neill LF

Wilyer Abreu RF

Garrett Cooper 1B

Dominic Smith DH

Vaughn Grissom 2B

Reese McGuire C

Ceddanne Rafaela SS

Tanner Houck P

How to watch

When: 8:10 p.m. ET

Where: Target Field, Minneapolis, Minn.

Broadcast info: NESN, WEEI 93.7 FM, WCCM 1490 AM (Spanish)